Common Pesticide Linked to More Than Double the Risk of Parkinson's Disease
- Long-term residential exposure to the insecticide chlorpyrifos was associated with more than a 2.5-fold higher risk of developing Parkinson's disease, adding to growing evidence that certain pesticides may pose a significant risk to brain health
- Researchers strengthened the findings by showing that chlorpyrifos produced similar Parkinson's-like changes in laboratory animals (via mice exposed by inhalation over 11 weeks), including loss of dopamine-producing nerve cells, harmful protein buildup, and chronic brain inflammation
- The pesticide disrupted the brain's natural recycling system in these animal models, allowing damaged proteins to accumulate inside nerve cells instead of being cleared away, which may help explain how exposure could contribute to Parkinson's disease in humans
- A lawsuit against Dow Chemical, Corteva and FMC Corporation, the companies that developed and originally marketed chlorpyrifos, alleges they failed to adequately warn users about the pesticide's neurological risks, bringing renewed attention to the dangers faced by agricultural and pest control workers
- Reducing repeated pesticide exposure, supporting gut health, staying physically active, managing stress, and maintaining healthy vitamin D levels are practical steps that may help support long-term brain health, though evidence connecting them specifically to Parkinson's disease risk is still developing
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