Erythritol May Impair Blood Vessel Function in the Brain and Raise Stroke Risk
- In a laboratory study, erythritol disrupted several functions in cultured human brain blood vessel cells, raising concerns that its effects extend beyond blood sugar and calorie content
- Erythritol increased oxidative stress while reducing nitric oxide production by about 20%, interfering with a key process that helps your blood vessels relax and regulate blood flow
- The sweetener increased production of endothelin-1, which promotes blood vessel constriction, by about 30%, further shifting the balance away from healthy blood vessel function
- Erythritol-treated cells failed to activate their normal clot-clearing response when researchers exposed them to a clotting signal, suggesting another way the sweetener could interfere with healthy brain blood vessel function
- Avoiding erythritol starts with checking ingredient lists — it appears in many products not obviously marketed as sugar-free — and choosing natural sweeteners like ripe fruit, raw honey or maple syrup in moderation rather than replacing it with another artificial substitute
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