Hidden Fat in the Pancreas and Abdomen Linked to Brain Aging and Cognitive Decline
- Hidden fat stored deep inside organs, especially the pancreas and abdomen, links to brain shrinkage, cognitive decline, and a higher risk of neurologic disease even when your weight looks normal
- An MRI-based study of 25,997 adults found that fat distribution patterns inside the body predict brain aging and cognitive outcomes more strongly than body mass index (BMI) alone
- People with high pancreatic fat showed around 30% fat concentration in the pancreas, which was up to six times higher than lean individuals and tied to extensive gray matter loss
- The "skinny fat" profile involved high internal abdominal fat despite only moderate BMI, with men showing the steepest decline in brain volume and slower thinking speed
- Simple metabolic assessments like fasting insulin, HOMA-IR, CRP, lipid profiles, and waist-based ratios offer practical ways to detect hidden risks early, before obvious symptoms appear
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