Podcast # 341: Tenecteplase vs. Alteplase
Author: Rachel Beham, PharmD
Educational Pearls:
- Tenecteplase is more specific for fibrin and has a longer half-life than alteplase.
- In setting of ischemic stroke, tenecteplase before thrombectomy was associated with a statistically higher incidence of reperfusion and better functional outcome than alteplase.
References
Bruce C.V. Campbell B et al (2018). Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke. New England Journal of Medicine. 378:1573-1582
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