Podcast 700: Analgesics for Acute Musculoskeletal Pain

Contributor: Aaron Lessen, MD

Educational Pearls:

• Recent RCT compared pain relief in patients receiving five medications for acute musculoskeletal pain
• • Acetaminophen 1000mg/ibuprofen 400 mg
  • Acetaminophen 1000mg/ibuprofen 800 mg
  • Acetaminophen 300 mg/codeine 30 mg
  • Acetaminophen 300mg/hydrocodone 5mg
  • Acetaminophen 325mg/oxycodone 5mg
• No significant difference in pain relief at 1 and 2 hours between all of 5 groups

References

Bijur PE, Friedman BW, Irizarry E, Chang AK, Gallagher EJ. A Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department. Ann Emerg Med. 2021;77(3):345-356. doi:10.1016/j.annemergmed.2020.10.004

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