49ERS SQUAD SHOW: HOME OPENER On the Horizon, Can 49ers Start 3-0?

The San Francisco 49ers look to continue their hot start as they take on the Arizona Cardinals in their first on-field action at Levi's Stadium in the 2025 NFL season. The San Francisco 49ers, who are 7-9 against the NFC West foe in the Kyle Shanahan era, dropped both of their matchups against the Arizona Cardinals last season.