Indianapolis Colts WITHOUT Charvarius Ward, Maybe Laiatu Latu vs. Denver Broncos

The Indianapolis Colts have a huge early-season AFC matchup with the Denver Broncos on Sunday, but they'll be without Charvarius Ward, and maybe Laiatu Latu as well. How much will that affect the Colts' defense against Sean Payton, Bo Nix, and the Broncos' offense. Offensively, can Daniel Jones keep it rolling against one of the NFL's best defenses? Who wins this game, and why?