Sameer Dossani on Gut Health, Carnivore Transition, and Cholesterol Science

In this episode of The Feldman Protocol, how should researchers and clinicians weigh insulin resistance against lipid markers when assessing cardiovascular risk? Dave Feldman sits down with Sameer Dossani (PhD, anthropology; health coach specializing in autoimmune and gut conditions) to explore human evolutionary dietary history, the origins of metabolic disease across ancient cultures, the lean mass hypersponder phenotype and ketone production, challenges in science communication, and the role of AI in personalized health.

📎 Mentioned in this episode:

• 1:23:33 – Bradford Hill 1965 — 'Environment and Disease' (criteria paper): `https://pmc.ncbi.nlm.nih.gov/articles/PMC1898525/`

• 1:33:20 – Ramsden 2015 re-analysis — Minnesota Coronary Experiment & Sydney Diet Heart Trial: `https://doi.org/10.1136/bmj.i1246`

• 2:23:35 – Zero-fiber vs high-fiber constipation RCT (2012) — discussed by Nick Norwitz: `https://www.wjgnet.com/1007-9327/full/v18/i33/4593.htm`

• 3:04:05 – Sameer Dossani's Linktree (all links): `https://linktr.ee/SameerDossani`

• 3:04:07 – Sameer Dossani's YouTube channel — @meatheels: `https://www.youtube.com/@MeatHeals`

🔥 This episode is sponsored by us --

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Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open and introduction

1:05 – Sameer's background and credentials

3:42 – Human origins and migration out of Africa

9:20 – Career in international economics and NGOs

15:34 – Ancient medicine and carbohydrate restriction

22:31 – Food culture, comfort eating, and self-soothing

34:12 – Human evolutionary diet: specialist vs. generalist

43:23 – Persistence hunting, sweat glands, and melanin

55:29 – Platform suppression and content challenges

1:03:03 – Sameer's personal health journey and diet shift

1:14:10 – Reaven's insulin resistance study and LDL findings

1:23:30 – Bradford Hill criteria and epidemiological data

1:33:09 – Minnesota Coronary experiment and withheld data

1:43:58 – Ketogenic diets, euketonemia, and fad diet framing

1:54:34 – LMHR study: plaque progression and CLEARLY analysis

2:04:27 – Statin pleiotropic effects and pharmaceutical trade-offs

2:18:20 – Own Your Labs Q&A: protein, muscle, and gut health

2:32:01 – Gut health, sleep, fatigue, and meal timing

2:46:26 – LMHR ketone production explained by Dave

2:52:04 – Changing the narrative: data, science, and next steps

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