TWiV 1370: Clinical Update with Dr. Daniel Griffin

In his weekly clinical update, Daniel Griffin and Vincent Racaniello are distressed by the continued upheaval of leadership at the CDC, recent news of H5 highly pathogenic influenza virus found on mink farms in Utah and in the polar bear population of Greenland, continuing spread of dengue virus in Florida and screwworm in the US, the Ebola outbreak in Kenya, identification of cross-reactive T cells following administration of VSV-ZEBOV-GP vaccine and re-addressing vaccination policy changes in Florida and the global burden of measles infection before Dr. Griffin deep dives into recent statistics RSV, influenza, SARS-CoV-2 infections and measles, ineffectiveness of the measles vaccine in infants under 9 months old, efficacy of high dose and standard dose of the influenza vaccine for the elderly, familial susceptibility to SARS-CoV-2 infection and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode C.D.C. Deputy Director Resigns After Four Months in the JobFinds(NY Times) Preliminary report on H5N1 highly pathogenic avian influenza in Utah mink, August 2026(Virological) Evidence of Exposure to Highly Pathogenic Avian Influenza H5 Viruses in East Greenland Polar Bears (CDC: Emerging Infectious Diseases) Florida counties declare emergency over wildly unusual dengue outbreak (Washington Post) Dengue (WHO:Dengue) Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) Cross-reactive T-cell responses against BDBV in humans after rVSVΔG-ZEBOV-GP vaccination (LANCET: Infectious Diseases) Kenya reports 2nd Ebola death as Nigeria races to understand transmission of index patient(CIDRAP) Kenya reports second death from Ebola (Reuters) Ebola DRC (X) Ebola dashboard (ebola.fyi) EBOLA: The Democratic Republic of the Congo, 2026(WHO) Projected effects of removing school-entry vaccination requirements on measles transmission in Florida (PNAS) Removing Florida vaccination requirements: Clinical Update TWiV 1352 (microbeTV) TWiV 1369: Florida Model Makes Measles Great Again (microbeTV) Global and regional burden of measles and vaccine coverage among children under 5 years, 1990−2023: a Global Burden of Disease Study (Nature Medicine) Global measles cases in kids rose 40% from 2020 to 2023, study estimates(CIDRAP) As measles soars in Pennsylvania, some parents are vaccinating their babies early (CIDRAP) Immunogenicity, effectiveness, and safety of measles vaccination in infants younger than 9 months: a systematic review and meta-analysis (LANCET: Infectious Diseases) Guidance for measles in pregnancy and congenital measles (Pennsylvaina Department of Health) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) Utah measles outbreak response (Utah Department of Health and Human Services) Utah Measles Dashboard (Utah Department of Health and Human Services) Measles (VDH: Virginia Department of Health) Tracking Measles Cases in the U.S. (Johns Hopkins) HAP’s Latest News Pa. Launches New Measles Dashboard (Hospital + HealthSystem Association of Pennsylvania) Measles (Commonwealth of Pennsylvania) Measles Dashboard (New York State: Department of Health) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Measles Cases and Outbreaks (CDC: Rubeola) Laboratory Testing for Measles (CDC: Measles (Rubeola) Measles Clinical Diagnosis Fact Sheet (CDC: Measles (Rubeola) Measles Serology Testing (CDC: Measles (Rubeola) First evidence of measles virus detected from exhaled breath in humans (CMI:Clinical Microbiology and Infection) New York State Seasonal Respiratory Virus Dashboard(New York State: Department of Health) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) WHO updates all 3 viral strains to be included in fall flu shots(CIDRAP) Effectiveness of high-dose versus standard-dose influenza vaccines against severe respiratory and secondary cardiovascular outcomes in adults aged ≥80 years (CMI: Clincial Microbiology and Infection) Humoral Immunogenicity of mRNA-1010, an mRNA-based Seasonal Influenza Vaccine, in Adults ≥50 Years (OFID) FDA vaccine advisers recommend adding subclade K to fall shots(CIDRAP) Weekly surveillance report: cliff notes (CDC FluView) OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) RSV: Wastewater scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) US respiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Moderna Receives U.S. FDA Approval for Updated 2026-2027 COVID-19 Vaccines (Moderna) Novavax’s Partnership Strategy Continues to Deliver with XFG-adapted Nuvaxovid™ Approvals in the U.S., EU and Japan for 2026-2027 Vaccination Season (novavax) Pfizer and BioNTech Receive U.S. FDA Approval for XFG-adapted COVID-19 Vaccine(Pfizer) FDA approves new COVID vaccines(CIDRAP) Coronavirus Disease 2019 (COVID-19) Hospitalization Surveillance Network (COVID-NET) (CDC: Covid) Familial factors in SARS-CoV-2 susceptibility and COVID-19 severity: a nationwide Danish study of adult twins and their spouses (International Journal of Epidemiology) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) Understanding Coverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulation guidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Reaching out to US house representative Letters read on TWiV 1370 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected] Content in this podcast should not be construed as medical advice.