TWiV 860: Evading a Toll on the road to RNA vaccines

TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Hall ( ASV ) Columbia University BSL-3 Manager position RNA modifications suppress innate recognition (Immunity) Critical contribution of pseudouridine (Front Cell Dev Biol) Rich Condit reminisces (YouTube) Letters read on TWiV 860 Timestamps by Jolene . Thanks! Weekly Picks Dickson - NASA Research Launches a New Generation of Indoor Farming Kathy - How Pfizer scientists transformed an old drug lead into a COVID-19 antiviral Rich - Fermi paradox Vincent - Racism not Race by Joe Graves Listener Picks Jay – Restoration of Ave Maria John – Pandemic humor Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]